Matthew J. Will

Associate Professor

340E Life Sciences Center
(573) 884-2570

Lab: Behavioral Neuroscience

Research Interests

The focus of my laboratory is to apply methods of behavioral neuroscience towards the study of drug addiction and obesity. Using an animal model, we attempt to reveal the neural substrates that underlie the reinforcement process that contributes to the intake of addictive drugs and natural rewards, such as food. Our research addresses these concerns and questions through an integrative approach of behavioral, pharmacological, and molecular biological techniques.

Graduate student Howard presenting at Society for Neuroscience in San Diego

Graduate student Patrick Hecht presenting at Society for Neuroscience in San Diego

Undergraduate student Matt McCabe presenting at Society for Neuroscience in San Diego

Selected Publications

MJ Will, MM Mccabe, KE Parker, HW Johns, MD Roberts, FW Booth. Forced Sedentary Home Cage Conditions Decrease Cocaine-Induced Locomotor Stimulation In Rats. (in prep).

KE Parker, MM McCabe, F Odu, D Cornelison, R Sharma, MM Thakkar, MJ Will. Basolateral amygdala mediation of feeding behavior driven by intra-accumbens DAMGO: role of hypothalamic orexin and VTA dopaminergic neurons. (in prep).

MJ Will, JG McCall, KE Parker. Intra-accumbens opioids potentiate conditioned place preference for a high-fat diet. (submitted).

KE Parker, JG McCall, SR McGuirk, S Trivedi, DK Miller, MJ Will. Co-stimulation with CB1 and µ-opioid agonists within the nucleus accumbens produces synergistic feeding behaviors associated with a palatable high-fat diet. (submitted).

PM Hecht, MJ Will, TR Schachtman, L Welby, DQ Beversdorf. (2014). Effect of Beta-Adrenergic Antagonist on a Novel Cognitive Flexibility Task in Rodents. Behavioral Brain Research. Mar 1;260:148-54.

KE Parker; HW Johns; TG Floros; MJ Will. (2014). Central amygdala opioid transmission is necessary for increased high-fat intake following 24-hour food deprivation, but not following intra-accumbens opioid administration. Behavioral Brain Research. Mar 1,260:131-8.

AS Sage, SC Vannest, KH Fan, MJ Will, SZ Lever, JR Lever, DK Miller. (2013). N-Phenylpropyl-N'-(3-methoxyphenethyl)piperazine (YZ-185) Attenuates the Conditioned-Rewarding Properties of Cocaine in Mice. ISRN Pharmacol. Sep 5;2013:546314.

Baldo BA, Pratt WE, Will MJ, Hanlon EC, Bakshi VP, Cador M. (2013) Principles of motivation revealed by the diverse functions of neuropharmacological and neuroanatomical substrates underlying feeding behavior. Neurosci Biobehav Rev. doi:pii: S0149-7634(13)00053-5. 10.1016/j.neubiorev.2013.02.017.

KL Jones, MJ Will, PM Hecht, CL Parker, DQ Beversdorf. (2013). Maternal diet rich in omega-6 polyunsaturated fatty acids during gestation and lactation produces autistic-like sociability deficits in adult offspring. Behavioral Brain Research. Feb 1;105(3):661-8.

SW Fowler, JM Walker, D Klakotskiaia, MJ Will, P Serfozo, A Simonyi, TR Schachtman. (2013). Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning task performance in rodents. Neurobiol Learn Mem. Jan;9925-31.

MD Roberts, L Gilpin, KE Parker, TE Childs, MJ Will, FW Booth. (2012) “Dopamine D1 receptor modulation in nucleus accumbens lowers voluntary wheel running in rats bred to run high distances.” Physiol Behav. Feb 1;105(3):661-8.