Matthew J. Will
Associate Professor |
340E Life Sciences Center
Lab: Behavioral Neuroscience
The focus of my laboratory is to apply methods of behavioral neuroscience towards the study of drug addiction and obesity. Using an animal model, we attempt to reveal the neural substrates that underlie the reinforcement process that contributes to the intake of addictive drugs and natural rewards, such as food. We also investigate the phenomenon by which exposure to environmental stress can augment the reinforcing value of both drugs of abuse and food. Our research addresses these concerns and questions through an integrative approach of behavioral, pharmacological, and molecular biological techniques.
Graduate student Kyle Parker and Dr. Thakkar
Missouri Chapter of Society for Neuroscience - poster session
PM Hecht, MJ Will, T Schachtman, L Welby, DQ Beversdorf. Effect of Beta-Adrenergic Antagonist on a Novel Cognitive Flexibility Task in Rodents. PNAS (under review).
KE Parker; HW Johns; TG Floros; MJ Will. Central amygdala opioid transmission is necessary for increased high-fat intake following 24-hour food deprivation, but not following intra-accumbens opioid administration. Behavioral Brain Research. (under review).
Baldo BA, Pratt WE, Will MJ, Hanlon EC, Bakshi VP, Cador M. (2013) Principles of motivation revealed by the diverse functions of neuropharmacological and neuroanatomical substrates underlying feeding behavior. Neurosci Biobehav Rev. doi:pii: S0149-7634(13)00053-5. 10.1016/j.neubiorev.2013.02.017.
KL Jones, MJ Will, PM Hecht, CL Parker, DQ Beversdorf. (2013). Maternal diet rich in omega-6 polyunsaturated fatty acids during gestation and lactation produces autistic-like sociability deficits in adult offspring. Behavioral Brain Research. Feb 1;105(3):661-8.
SW Fowler, JM Walker, D Klakotskiaia, MJ Will, P Serfozo, A Simonyi, TR Schachtman. (2013). Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning task performance in rodents. Neurobiol Learn Mem. Jan;9925-31.
MD Roberts, L Gilpin, KE Parker, TE Childs, MJ Will, FW Booth. (2012) “Dopamine D1 receptor modulation in nucleus accumbens lowers voluntary wheel running in rats bred to run high distances.” Physiol Behav. Feb 1;105(3):661-8.