Brett Froeliger

Brett Froeliger, PhD
Professor; Director, Cognitive Neuroscience Systems (CNS) Core Facility
111 McAlester Hall

My program of research has been continuously funded by NIH since 2012. I have published over 60 peer reviewed manuscripts, book chapters and reviews articles and am an Associate Editor for Nicotine & Tobacco Research, Frontiers in Psychiatry and Evidence-Based Complementary and Alternative Medicine. In addition to conducting research, I'm dedicated to educating the next generation of addiction scientists.

Selected Publications: 


  • Halbert CH, Jefferson MS, Danielson C, Froeliger, B, Giordanoa A, Thaxton J. (in press). An observational study and randomized trial of stress reactivity in cancer disparities. Health Psychology.
  • McConnell, P. A., E. L. Garland, J. K. Zubieta, R. Newman-Norlund, S. Powers and Froeliger, B. (2020). "Impaired frontostriatal functional connectivity among chronic opioid using pain patients is associated with dysregulated affect." Addict Biol. PMID: 30945801
  • Newman-Norlund, R., Gibson, M., McConnell, P., Froeliger, B. (2020). Dissociable effects of theta-burst repeated transcranial magnetic stimulation to the inferior frontal gyrus on inhibitory control in nicotine addiction. Frontiers in Psychiatry. Apr 15;11:260. PMID: 32351412
  • Garland, E.L., Atchley, R., Howard, M., Zubieta, J-K., Froeliger, B. (2019). Mindfulness-Oriented Recovery Enhancement Restructures Reward Processing Among Chronic Opioid Users: Neurophysiological and Affective Evidence. Science Advances 5(10). PMID 31663023
  • Tomko, R. L., Froeliger, B., McClure, E. A., Saladin, M.E., and Gray, K.M. (2019). Gender Differences in Smoking Latency Following Exposure to Stressful Images Administered in Naturalistic Settings. Journal of Womens Health. 28 (11): 1593-1593.
  • Fridriksson, J.F., Rorden, C., Newman-Norlund, R., Froeliger, B., Thrasher, J. (2018). Smokers' Neurological Responses to Novel and Repeated Health Warning Labels (HWLs) from Cigarette Packages. Frontiers in Psychology.
  • Garland EL, Bryan CJ, Kreighbaum L, Nakamura Y, Howard MO & Froeliger B. (2018). Prescription opioid misusing chronic pain patients exhibit dysregulated context-dependent associations: Investigating associative learning in addiction with the Cue-Primed Reactivity Task. Drug and Alcohol Dependence. Mar 27;187:13-21.PMID: 29626741
  • Garland, E.L., Hanley, A.W., Bedford, C., Zubieta, J.-K., Howard, M.O., Nakamura, Y., Donaldson, G., & Froeliger, B. (2018). Reappraisal deficits promote craving and emotional distress among chronic pain patients at risk for prescription opioid misuse. Journal of Addictive Diseases. Jun 4:1-9. PMID: 29863439.
  • Serfaty, S., Gale, G., Beadman, M., Froeliger, B., & Kamboj, S. K. (2018). Mindfulness, Acceptance and Defusion Strategies in Smokers: a Systematic Review of Laboratory Studies. Mindfulness (N Y), 9(1), 44-58. doi:10.1007/s12671-017-0767-1
  • Badran, B.W., Austelle, C.W., Smith, N.R., Glusman, C.E., Froeliger, B., Garland, E.L., Borckardt, J.J., George, M.S., Short, B. (2017). A double-blind study exploring the use of transcranial direct current stimulation (tic’s) to potentially enhance mindfulness meditation (E-meditation). Brain Stimulation. Jan-Feb; 10 (1): 152-154. PMID: 27839723.
  • Carpenter MJ, Heckman BW, Wahlquist AE, Wagener TL, Goniewicz ML, Gray KM, Froeliger B, Cummings KM. A naturalistic, randomized pilot trial of e-cigarettes: Uptake, exposure, and behavioral effects. Cancer Epidemiology, Biomarkers & Prevention. 2017;26:1795-803. PMCID: 5713898.
  • Froeliger, B., Mathew, A.R., McConnell, P.A., Eichberg, C., Saladin, M.E., Carpenter, M.J., Garland, E.L. (2017). Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of Mindfulness-Oriented Recovery Enhancement for Cigarette Smokers. Evidence-Based Complementary and Alternative Medicine: eCAM 2017.
  • Froeliger, B., McConnell, P.A., Sweitzer, M.A., Bell, S., Kozink, R.V., Eichberg, C., Gray, K.M., McClernon, F.J. (2017). Association Between Baseline Corticothalamic-Mediated Inhibitory Control and Smoking Relapse Vulnerability. JAMA Psychiatry. Mar 1. doi:10.1001/jamapsychiatry.2017.0017
  • Garland, E.L., Howard, M.O.. Zubieta, J.K., Froeliger, B. (2017).  Restructuring Hedonic Dysregulation in Chronic Pain and Prescription Opioid Misuse: Effects of Mindfulness-Oriented Recovery Enhancement on Responsiveness to Drug Cues and Natural Rewards. Psychotherapy and Psychosomatics. Feb 10;86(2):111-112. PMID: 28183077
  • Germeroth, L.J., Carpenter, M.J., Baker, N.L., Froeliger, B., LaRowe, S.D., Saladin, M.E. (2017). A Brief Memory Updating Intervention Significantly Attenuates Smoking Behavior. JAMA Psychiatry. Feb 1.PMID: 28146243.
  • Meier, E., Wahlquist, A.E., Heckman, B.W., Cummings, K.M., Froeliger, B., Carpenter, M.J. (2017). A Pilot Randomized Crossover Trial of E-cigarette Sampling Among Smokers. Nicotine and Tobacco Research, Feb; 19 (2): 176-182. PMID: 27613880.
  • Addicott, M.A., Sweitzer, M.M., Froeliger, B., McClernon, F.J. (2015). Increased functional connectivity in an insula-based network is associated with improved smoking cessation outcomes. Neuropsychopharmacology; Oct; 40 (11): 2648-56. PMID: 25895453.
  • Froeliger, B., McConnell, P.A., Stankeviciute, N., McClure, E.A., Kalivas, P.W., Gray, K.M. (2015). The effects of N-Acetylcysteine on frontostriatal resting-state functional connectivity, withdrawal symptoms and smoking abstinence: A double-blind, placebo-controlled fMRI pilot study. Drug and Alcohol Dependence. doi:10.1016/j.drugalcdep.2015.09.021. PMID: 26454838.
  • Garland, E.L., Froeliger, B., Howard, M.O. (2015). Neurophysiological Evidence for Remediation of Reward Processing Deficits in Chronic Pain and Opioid Misuse Following Treatment with Mindfulness-Oriented Recovery Enhancement: Exploratory ERP Findings from a Pilot RCT. Journal of Behavioral Medicine. Jun;82(3):448-59. doi: 10.1007/s10865-014-9607-0. Epub 2014 Nov 11. PMID: 25385024.
  • Garland, E, Hanley, A., Farb, N., Froeliger, B. (2015). State Mindfulness During Meditation Predicts Enhanced Cognitive Reappraisal. Mindfulness. Apr 1;6(2):234-242. PMID: 26085851.
  • Heckman, B., Carpenter, M., Correa, J., Wray, J., Saladin, M., Froeliger, B., Drobes, D., Brandon, T. (2015). Acute Negative Affect Manipulations Increase Smoking Behavior: A Meta-Analysis. Addiction. May;110(5):751-60. PMID: 25641624.
  • McClure, E.A., Baker, N.L., Gipson, C.D., Carpenter, M.J., Roper, A., Froeliger, B.E, Kalivas, P.W., Gray, K.M (2015). An open-label pilot trial of N-acetylcysteine and varenicline in adult cigarette smokers. The American Journal of Drug and Alcohol Abuse. Jan;41(1):52-6. PMID: 25062287.
  • McConnell, P.A., Froeliger, B.  (2015). Mindfulness, Mechanisms and Meaning: Perspectives from the Cognitive Neuroscience of Addiction. Psychological Inquiry. PMID: 26924915.
  • Addicott, M.A., Froeliger, B., Kozink, R.V., Van Wert, D.M., Westman, E.C., Rose, J.E., McClernon, F.J. (2014). Nicotine and non-nicotine smoking factors differentially modulate craving, withdrawal and cerebral blood flow as measured with arterial spin labeling. Neuropsychopharmacology. Nov;39(12):2750-9. PMID: 24820539.
  • Garland, E.L., Manusov, E., Froeliger, B., Kelly, A., Williams, J., Howard, M. (2014). Mindfulness-Oriented Recovery Enhancement for Chronic Pain and Prescription Opioid Misuse: Results from an Early Stage Randomized Controlled Trial. Journal of Consulting and Clinical Psychology. Jun;82(3):448-59. PMID: 24491075.
  • Newman-Norlund, R., Thrasher, J., Fridrikson, J., Brixius, W., Froeliger, B., Hammond, D., Cummings, M. (2014). Neural biomarkers for assessing the effects of different types of imagery in pictorial health warning labels on cigarette packaging. BMJ Open. Dec 31;4(12). PMID: 25552613.
  • Froeliger, B., Modlin, L.A., Kozink, R.V., Wang, L., Garland, E.L., Addicott, M.A., McClernon, F.J. (2013). Frontoparietal Attentional Network Activation Differs Between Smokers and Nonsmokers During Affective Cognition. Psychiatry Research: Neuroimaging. Jan 30;211(1):57-63. PMID: 23154092.
  • Garland, E. L., Froeliger, B., Zeidan, F., Suveg, K., & Howard, M. O. (2013). The downward spiral of chronic pain, prescription opioid misuse, and addiction: Cognitive, affective, and neuropsychopharmacologic pathways. Neuroscience & Biobehavioral Reviews. Dec;37(10 Pt 2):2597-607. PMID: 23988582.
  • Froeliger, B. Garland, E., & McClernon, F.J. (2012). Yoga meditation practitioners exhibit greater gray matter volume and fewer reported cognitive failures: Results of a preliminary voxel-based morphometric analysis. Evidence-Based Complementary and Alternative Medicine: eCAM 2012: 821307. PMID: 23304217.
  • Froeliger, B., Beckham, J.C., Feldman, M., Kozink, R.V., McClernon, F.J. (2012). Effects of nicotine administration on emotional reactivity in PTSD and non-PTSD smokers: Results of a preliminary fMRI study. Advances in Pharmacological Sciences, vol 2012, Article ID 265724, 6 pages. PMID: 22719754.
  • Froeliger, B., Garland, E.L., Modlin, L.A., McClernon, F.J. (2012). Neurocognitive correlates of the effects of yoga meditation practice on emotion and cognition: a pilot study. Frontiers in Integrative Neuroscience, 6. PMID: 22855674
  • Froeliger, B., Garland, E.L., Kozink, R.V. et al., (2012) Meditation-State Functional Connectivity (msFC): Strengthening of the Dorsal Attention Network and Beyond, Evidence-Based Complementary and Alternative Medicine. vol. 2012, Article ID 680407, 9 pages, 2012. PMID: 22536289.
  • Froeliger, B., Modlin, L.A., Kozink, R.V., Wang, L., McClernon, F.J. (2012). Smoking Abstinence and Depressive Symptoms Modulates the Executive Control System During Emotional Information Processing. Addiction Biology,17, 668-679. PMID: 22081878.
  • Froeliger, B., Modlin, L.A., Wang, L., Kozink, R.V., McClernon, F.J. (2012). Nicotine Withdrawal Modulates Frontal Brain Function During an Affective Stroop Task. Psychopharmacology, 220, 707-18. PMID: 21989805.
  • Rose, J.E., McClernon, F.J., Froeliger, B., Behm, F.M., Preud'homme, X., Krystal, A. (2011). Repetitive transcranial magnetic stimulation (rTMS) of the superior frontal gyrus modulates craving for cigarettes. Biological Psychiatry, 70, 794-799. PMID: 21762878.
  • Froeliger, B., Kozink, R.V., Rose, J.E., Behm, F.M., Salley, A.N., and McClernon, F.J. (2010). Hippocampal and striatal grey matter volume are associated with a smoking cessation treatment outcome: Results of an exploratory voxel-based morphometric analysis. Psychopharmacology, 210, 577-583. PMID: 20424827.
  • Kozink, R. V., Lutz, A. M., Rose, J. E., Froeliger, B., & McClernon, F. J. (2010). Smoking withdrawal shifts the spatiotemporal dynamics of neurocognition. Addiction Biology, 15, 480-490. PMID: 21040240.
  • Froeliger, B., Gilbert, D.G., & McClernon, F.J. (2009). Effects of Nicotine on Novelty Detection and Memory Recognition Performance: Double-Blind, Placebo-Controlled Studies of Smokers and Nonsmokers. Psychopharmacology, 205, 625-633. PMID: 19488741.
  • Gilbert, D. G., Sugai, C., Zuo, Y., Rabinovich, N. E., McClernon, F. J., & Froeliger, B. E. (2007). Brain indices of nicotine’s effects on attentional bias to smoking and emotional pictures and to task-relevant targets. Nicotine and Tobacco Research, 9, 351-363. PMID: 17365767.


  • Fisher, M.L., Pauly, J.R, Froeliger, B., Turner, J.R. (2020). Translational Research in Nicotine Addiction. Cold Spring Harbor Perspectives in Medicine. Cold Spring Habor Laboratory Press.
  • Garland, E.L., Bell, S., Atchley, R., Froeliger, B. (2017). Emotion Dysregulation in Addiction.  Oxford Handbook on Emotion Dysregulation, Oxford University Press.
  • Garland, E.L., & Froeliger, B.E. (2013). Mindfulness training targets addiction at the attention-emotion interface: A neurocognitive framework. In E. Langer, A. Le, & C. Ngoumen (eds.), Handbook of Mindfulness, Wiley-Blackwell.