Matthew J. Will

Matthew J. Will
Associate Professor
207 McAlester Hall
(573) 884-2570
Research Interests: 

The focus of my laboratory is to apply methods of behavioral neuroscience towards the study of neural systems mediating the motivational aspects of drug of abuse and natural rewards, including food and exercise. Our research addresses these concerns and questions through an integrative approach of behavioral, pharmacological, and molecular biological techniques.

Selected Publications: 

Lee JR, Muckerman JE, Wright AM, Davis DJ, Childs TE, Gillespie CE, Vieira-Potter VJ, Booth FW, Ericsson AC, Will MJ. (2017) Sex Determines Effect of Physical Activity on Diet Preference: Association of Striatal Opioids and Gut Microbiota Composition. Behavioral Brain Research (in press).

Davis DJ, Hecht PM, Jasarevic E, Beversdorf DQ, Will MJ, Fritsche K, Gillespie CH. (2016) Sex-specific effects of docosahexaenoic acid (DHA) on the microbiome and behavior of socially-isolated mice. Brain Behav Immun.  Sep 9. pii: S0889-1591(16)30412-3. doi: 10.1016/j.bbi.2016.09.003. [Epub ahead of print] PMID: 27621225

Smethells JR, Zlebnik NE, Miller DK, Will MJ, Booth F, Carroll ME. (2016) Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running.  Drug Alcohol Depend. Oct 1;167:163-8. PMID: 27567437

Park YM, Kanaley JA, Padilla J, Zidon T, Welly RJ, Will MJ, Britton SL, Koch LG, Ruegsegger GN, Booth FW, Thyfault JP, Vieira-Potter VJ. (2016) Effects of intrinsic aerobic capacity and ovariectomy on voluntary wheel running and nucleus accumbens dopamine receptor gene expression.  Physiol Behav. Oct 1;164(Pt A):383-9. 

Parker KE, McCabe MP, Johns HW, Lund DK, Odu F, Sharma R, Thakkar MM, Cornelison DD, Will MJ. (2015). Neural activation patterns underlying basolateral amygdala influence on intra-accumbens opioid-driven consummatory versus appetitive high-fat feeding behaviors in the rat. Behavioral Neuroscience. Dec;129(6):812-21.

Ruegsegger GN, Toedebusch RG, Will MJ, Booth FW. (2015). Mu opioid receptor modulation in the nucleus accumbens lowers voluntary wheel running in rats bred for high running motivation. Neuropharmacology. Oct;97:171-81.

Parker KE, McCall JG, McGuirk SR, Trivedi S, Miller DK, Will MJ. (2015). Effects of co-administration of 2-arachidonylglycerol (2-AG) and a selective µ-opioid receptor agonist into the nucleus accumbens on high-fat feeding behaviors in the rat. Brain Res. Aug 27;1618:309-15.

Hoertel HA, Will MJ, Leidy HJ.  (2014). A randomized crossover, pilot study examining the effects of a normal protein vs. high protein breakfast on food cravings and reward signals in overweight/obese "breakfast skipping", late-adolescent girls. Nutrition Journal. Aug 6;13:80. 

PM Hecht, MJ Will, TR Schachtman, L Welby, DQ Beversdorf. (2014). Effect of Beta-Adrenergic Antagonist on a Novel Cognitive Flexibility Task in Rodents. Behavioral Brain Research. Mar 1;260:148-54.

KE Parker; HW Johns; TG Floros; MJ Will. (2014). Central amygdala opioid transmission is necessary for increased high-fat intake following 24-hour food deprivation, but not following intra-accumbens opioid administration. Behavioral Brain Research. Mar 1,260:131-8.

AS Sage, SC Vannest, KH Fan, MJ Will, SZ Lever, JR Lever, DK Miller. (2013). N-Phenylpropyl-N'-(3-methoxyphenethyl)piperazine (YZ-185) Attenuates the Conditioned-Rewarding Properties of Cocaine in Mice. ISRN Pharmacol. Sep 5;2013:546314.

Baldo BA, Pratt WE, Will MJ, Hanlon EC, Bakshi VP, Cador M. (2013) Principles of motivation revealed by the diverse functions of neuropharmacological and neuroanatomical substrates underlying feeding behavior. Neurosci Biobehav Rev. doi:pii: S0149-7634(13)00053-5. 10.1016/j.neubiorev.2013.02.017.

KL Jones, MJ Will, PM Hecht, CL Parker, DQ Beversdorf. (2013). Maternal diet rich in omega-6 polyunsaturated fatty acids during gestation and lactation produces autistic-like sociability deficits in adult offspring. Behavioral Brain Research. Feb 1;105(3):661-8.

SW Fowler, JM Walker, D Klakotskiaia, MJ Will, P Serfozo, A Simonyi, TR Schachtman. (2013). Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning task performance in rodents. Neurobiol Learn Mem. Jan;9925-31.

MD Roberts, L Gilpin, KE Parker, TE Childs, MJ Will, FW Booth. (2012) “Dopamine D1 receptor modulation in nucleus accumbens lowers voluntary wheel running in rats bred to run high distances.” Physiol Behav. Feb 1;105(3):661-8.